Robot Chicken, Venture Brothers and Family Guy are dominating Adult Swim so even the moderately successful Tim & Eric Great Job show has been in a precarious state of losing ground from its inception.
As for live action, British Imports like Garth Pherange's Dark Place, Look Around You, the Mighty Boosh and the Office have all done exceptionally well were as Tim & Eric's live action Shows, Tom goes to the Mayor, Psaul of the Molemen, Fat Guy in the Internet (or whatever it was called) have all done terribly. Only Tim & Eric Great Job! has done decently and with the recent alleged friction between Tim & Eric and other creative teams on Adult Swim (Venture Bros' Doc Hammer and Jackson Public for example) I guess they're fast losing support.
Anime unfortunately has been a declining venture in Adult Swim's priorities so its hard to say even now if the Big O would get renewed support. The creator has said he has an idea for a third season if someone is willing to fund it so it's not like the story was ended with Season 2.